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Tulane Study: Can a Perfume Ingredient Save Lives?
NEW ORLEANS — From Tulane University:
The chances of surviving massive blood loss from a traumatic injury such as a gunshot wound are around 50 percent. To survive, a patient needs two things to happen quickly: a large infusion of blood and coagulation at the wound to stop the bleeding.
The problem is one of these solutions prevents the other. Introducing a large amount of blood to those suffering a massive hemorrhage impairs the blood’s ability to clot, a condition known as coagulopathy.
“Coagulopathy of trauma is a major contributor to mortality, but no treatment has shown to be fully effective,” said Olan Jackson-Weaver, PhD, assistant professor of surgery at Tulane University School of Medicine and corresponding author on the study. “We were getting 60 percent mortality with our animal model. With dimethyl malonate, we got zero percent mortality, and the coagulopathy completely went away.”
Trauma is a leading cause of death in the United States especially for children and young adults as a result of gun violence.
Recent studies have shown that coagulopathy during massive hemorrhage treatment is most likely caused by the shedding of the glycocalyx, a barrier of sugars that surrounds and protects cells. In blood vessels, the glycocalyx lines the vessel walls and prevents blood from clotting. However, this is the first study to identify the cellular events that cause the glycocalyx to be ripped apart.
The study found that a large infusion of blood creates a spike in cellular metabolism which causes a change in structure to the cell membrane. This exposes the glycocalyx, allowing it to be chewed up by enzymes and mixed into the bloodstream, where it prevents clotting.
“People have been trying to figure out ways to move the needle a little bit on the death rate from massive hemorrhage for the last 20 or so years and nothing has really worked,” Jackson-Weaver said. “We’re hopeful that understanding these cellular-level events can help to develop something that actually does make a big difference.”
“We’ve established this pathway that causes coagulopathy, so if we can target it therapeutically with a pre-hospital drug or injection, we can hopefully save some lives,” Jackson-Weaver said.
